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Last Update: 7/28/2008
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Glioblastoma Multiforme Mutations

Large-scale build of homology models for proteins encoded by mRNA transcripts found to have somatic missense mutations in 22 glioblastoma multiforme (GBM) samples. Transcript IDs from CCDS , RefSeq and Ensembl. All models built with ModPipe 1.0 and MODELLER 9.1 [1, 2]. Graphics rendered with UCSF Chimera [3]. Mutations predicted to be near a ligand or a domain interface are indicated in the "Potential biological significance" column. The LIGBASE [4] and PIBASE [5] databases were used to make these predictions. Protein Descriptions from the UniProt Knowledge Base [6] and UCSC Genome Browser database [7]. References below.


Transcript ID

UniprotKB ID

Mutation

Potential Biological Significance

Protein Description

CCDS1002.1

Q8IZ97 R182H   CUG-BP and ETR-3 like factor 3 (Fragment).

CCDS10031.1

P08912 S274F   Muscarinic acetylcholine receptor M5.

CCDS10046.1

Q8N6Q1 V96F   Transmembrane and coiled-coil domains 5.

CCDS10172.1

O95395 S254L   Beta-1,6-N-acetylglucosaminyltransferase (GCNT3 protein) (Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase).

CCDS10305.1

P32297-2 L140S   Neuronal acetylcholine receptor subunit alpha-3 precursor.

CCDS10329.1

Q7Z7L9-2 S537R Near ligand Zinc finger and SCAN domain-containing protein 2 (Zinc finger protein 29 homolog) (Zfp-29).

CCDS10383.1

Q8TE56 D434G   ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

CCDS10420.1

Q96GC7 R264C    

CCDS10481.1

Q9GZN4 A32V   Brain-specific serine protease 4 precursor (EC 3.4.21.-) (BSSP-4) (Serine protease 22) (Serine protease 26) (Tryptase epsilon).

CCDS10491.1

Q86W42 V79I   THO complex subunit 6 homolog (WD repeat protein 58).

CCDS10586.1

Q68CK6 P486S   Hypothetical protein HYST1046.

CCDS10989.1

Q8N8N3 R70C   CDNA FLJ39166 fis, clone OCBBF2002805.

CCDS11103.1

Q8NFZ4 E577K   Neuroligin-2 precursor.

CCDS11118.1

P04637 C176F Near ligand Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).
P04637 G245D   Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).
P04637 G245S   Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).
P04637 R248W   Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).
P04637 R273C   Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).
P04637 R273H   Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).
P04637 R282W   Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).
P04637 V197E   Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).

CCDS11126.1

Q69YV7 A422G    

CCDS11264.1

P21359-2 R1809C   Neurofibromin (Neurofibromatosis-related protein NF-1) [Contains: Neurofibromin truncated].

CCDS11287.1

O75771-3 G315W   DNA repair protein RAD51 homolog 4 (R51H3) (RAD51-like protein 3) (TRAD).

CCDS11368.1

Q8IZW8 T425N   Tensin-4 precursor (C-terminal tensin-like protein).

CCDS11412.1

P53396 S525A   ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme).

CCDS11512.1

Q8IY85 P252S   Chromosome 17 open reading frame 57.

CCDS11568.1

O15335 Q282E   Chondroadherin precursor (Cartilage leucine-rich protein).

CCDS1165.1

Q96RD9 P206T Near domain interface Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

CCDS11684.1

Q6PIQ6 Q532H    

CCDS11840.1

P28827 M1220V   Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

CCDS11897.1

Q86SJ6 A601V   Desmoglein-4 precursor.

CCDS11988.1

O75635 R315H   Serpin B7 (Megsin) (TP55).

CCDS12128.1

Q9UGK3 E161A   Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

CCDS1229.1

P25189 Y187C   Myelin P0 protein precursor (Myelin protein zero) (Myelin peripheral protein) (MPP).

CCDS12458.1

O14842 R118W   Free fatty acid receptor 1 (G-protein coupled receptor 40).

CCDS1247.1

Q8TE12 C62Y   LIM homeobox transcription factor 1 alpha (LIM/homeobox protein LMX1A) (LIM/homeobox protein 1.1) (LMX-1.1).
Q8TE12 V239I   LIM homeobox transcription factor 1 alpha (LIM/homeobox protein LMX1A) (LIM/homeobox protein 1.1) (LMX-1.1).

CCDS12559.1

Q9H254 A38T   Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

CCDS12565.1

P09012 G99D   U1 small nuclear ribonucleoprotein A (U1 snRNP protein A) (U1A protein) (U1-A).

CCDS1281.1

P12259 V434M Near ligand Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

CCDS12816.1

Q9UKQ9 Y240D Near ligand Kallikrein-9 precursor (EC 3.4.21.-) (Kallikrein-like protein 3) (KLK- L3).

CCDS12859.1

Q9HCG1 P103L   Zinc finger protein Kr18 (HKr18).

CCDS12916.1

Q7L8F7 A414T   Hypothetical protein DKFZp434D0412 (Fragment).

CCDS12926.1

Q8TDY7 G54S   K562 cell derived leucine zipper like protein 1.

CCDS12977.1

Q6ZTD2 D278N Near ligand  
Q6ZTD2 Q433L Near ligand  

CCDS1305.1

Q9UNG2 V79M Near domain interface Tumor necrosis factor ligand superfamily member 18 (Glucocorticoid- induced TNF-related ligand) (hGITRL) (Activation-inducible TNF-related ligand) (AITRL).

CCDS13060.1

Q9BZZ2 D62Y   Sialoadhesin precursor (Sialic acid-binding Ig-like lectin 1) (Siglec- 1) (CD169 antigen).

CCDS1311.1

Q6PI48 E277G Near domain interface Aspartyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.12) (Aspartate--tRNA ligase) (AspRS).

CCDS13132.1

Q9BRP0 T222M   Transcription factor Ovo-like 2 (hOvo2) (Zinc finger protein 339).

CCDS13232.1

P42127 D109N   Agouti-signaling protein precursor (ASP) (Agouti switch protein).

CCDS13265.1

Q14498-2 R180Q   RNA-binding protein 39 (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Hepatocellular carcinoma protein 1) (Splicing factor HCC1).

CCDS13304.1

P18428 E363K   Lipopolysaccharide-binding protein precursor (LBP).

CCDS13320.1

Q9HBY8 R152G   Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

CCDS1332.1

Q8NAT2-2 R925H   Tudor domain-containing protein 5.

CCDS13675.1

P57078-2 P222Q   Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

CCDS13678.1

Q9ULJ3 G333S   Zinc finger protein 295 (Zinc finger and BTB domain-containing protein 21).

CCDS13712.1

Q8WU66 S605T   Protein TSPEAR precursor (TSP-EAR).
Q8WU66 T270M   Protein TSPEAR precursor (TSP-EAR).

CCDS13833.1

Q9BYH1-4 R817C   Seizure 6-like protein precursor.

CCDS13897.1

Q9Y295 R222H   Developmentally-regulated GTP-binding protein 1 (DRG 1).

CCDS13945.1

P15153 D47Y   Ras-related C3 botulinum toxin substrate 2 precursor (p21-Rac2) (Small G protein) (GX).

CCDS13985.1

Q6NTF7 P84L   Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H.

CCDS13999.1

O75791 S304P   GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CCDS1403.1

Q5T1V5 E288Q   Novel protein (Fragment).

CCDS14225.1

P32189 A402V   Glycerol kinase (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK).

CCDS14443.1

Q9BXC1 F248L   Probable G-protein coupled receptor 174.

CCDS14491.1

Q9H1B4 R50Q   Nuclear RNA export factor 5 (TAP-like protein 1) (TAPL-1).

CCDS14522.1

Q5JSK2 R534H   Novel protein (Fragment).

CCDS14543.1

P29400 P773S   Collagen alpha-5(IV) chain precursor.

CCDS1487.1

Q13751 A957T   Laminin subunit beta-3 precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

CCDS1496.1

O95259 K554N   Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

CCDS1775.1

P47989 H82N Near domain interface Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (EC 1.17.1.4) (XD); Xanthine oxidase (EC 1.17.3.2) (XO) (Xanthine oxidoreductase)].

CCDS1802.1

Q07889 E433K   Son of sevenless homolog 1 (SOS-1).

CCDS1863.1

Q9BWT3 V433I   Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme) (Neo- poly(A) polymerase) (Neo-PAP).

CCDS1976.1

Q7Z4S9 S13F Near domain interface Hypothetical protein.

CCDS2062.1

Q9UBY0 R160H   Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2).

CCDS2137.1

O00499-10 L402V   Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

CCDS2152.1

Q6DCA0 T230I   MGC4268 protein (Hypothetical protein MGC4268).

CCDS2272.1

O75431 I172N   Metaxin-2.

CCDS2311.1

O43795-2 A560T   Myosin-Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).
O43795-2 V991I   Myosin-Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).

CCDS2381.1

O75874 R132H Near ligand Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP).

CCDS2393.1

P31327 A303P   Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CCDS2436.1

Q9NP58 R638C   Mitochondrial ATP-binding cassette sub-family B member 6 (Mitochondrial ABC transporter 3) (Mt-ABC transporter 3) (Ubiquitously expressed mammalian ABC half transporter) (P-glycoprotein-related protein).

CCDS245.1

P34972 A244G   Cannabinoid receptor 2 (CB2) (CB-2) (CX5).

CCDS2453.1

Q8IWX5 A169V   Sphingosine-1-phosphate phosphatase 2 (EC 3.1.3.-) (Sphingosine-1- phosphatase 2) (SPPase2) (Spp2) (hSPP2).

CCDS2463.1

P35568 Y47C   Insulin receptor substrate 1 (IRS-1).

CCDS2492.1

P09923 A350V   Intestinal alkaline phosphatase precursor (EC 3.1.3.1) (IAP).

CCDS2493.1

O95672 P415L   Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein).

CCDS2500.1

Q8N5V2 R259Q   Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

CCDS2510.1

P22309 V169L   UDP-glucuronosyltransferase 1-1 precursor (EC 2.4.1.17) (UDP- glucuronosyltransferase 1A1) (UDPGT) (UGT1*1) (UGT1-01) (UGT1.1) (UGT- 1A) (UGT1A) (Bilirubin-specific UDPGT isozyme 1) (HUG-BR1).

CCDS279.1

Q5T142 P74L   Novel protein (Fragment).

CCDS2958.1

P40200 Y302H   T-cell surface protein tactile precursor (T cell-activated increased late expression protein) (CD96 antigen).

CCDS2998.1

Q12841 G87A   Follistatin-related protein 1 precursor (Follistatin-like 1).

CCDS3218.1

Q92847 V249M   Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor).

CCDS3259.1

Q04637 E876V   Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

CCDS329.1

P41143 T82M   Delta-type opioid receptor (DOR-1).

CCDS3319.1

Q86YC3 T366M Near domain interface Leucine-rich repeat-containing protein 33 precursor.

CCDS3352.1

Q9Y6A5 E680K   Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

CCDS3353.1

P22607 E466K   Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

CCDS3455.1

O60701 F420S   UDP-glucose 6-dehydrogenase (EC 1.1.1.22) (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH).

CCDS3495.1

P16234 I1050T   Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

CCDS3551.1

Q9Y5X5-4 V353A   Neuropeptide FF receptor 2 (Neuropeptide G-protein coupled receptor) (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77).

CCDS3589.1

Q13237 L136M   cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

CCDS3644.1

P29803 E307K   Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type II).

CCDS3771.1

Q6P2P2 D662N Near domain interface Hypothetical protein LOC90826.

CCDS3850.1

Q6T5J5 L15I Near ligand Hypothetical protein FLJ25801 (Fragment).

CCDS3915.1

Q13309-2 S135F   S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1).
Q13309-2 S168L   S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (p45skp2) (F-box/LRR-repeat protein 1).

CCDS3976.1

Q96E17 R49H   Ras-related protein Rab-3C.

CCDS3981.1

Q9UNQ2 E85K   Probable dimethyladenosine transferase (EC 2.1.1.-) (S- adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase) (18S rRNA dimethylase) (DIM1 dimethyladenosine transferase 1-like).

CCDS4033.1

P55085 C226S   Proteinase-activated receptor 2 precursor (PAR-2) (Thrombin receptor- like 1) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11).

CCDS404.1

O43617 P91R   Trafficking protein particle complex subunit 3 (BET3 homolog).

CCDS4124.1

Q8NBZ2 A707T    

CCDS421.1

Q13823 F421I Near ligand Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

CCDS4240.1

Q9Y5I0 R70T   Protocadherin alpha 13 precursor (PCDH-alpha13).

CCDS4320.1

P23415 R246W   Glycine receptor subunit alpha-1 precursor (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit).

CCDS4356.1

Q16445 T113M   Gamma-aminobutyric-acid receptor subunit alpha-6 precursor (GABA(A) receptor subunit alpha-6).

CCDS4372.1

Q12951 S129L   Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead- related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HNF-3/fork-head homolog 3) (HFH-3).

CCDS441.1

Q9UM19 P10H   Hippocalcin-like protein 4 (HLP4).

CCDS4468.1

Q96AR1 V106I    

CCDS4853.1

Q5T2D2 V76I   Trem-like transcript 2 protein precursor (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2).

CCDS4987.1

Q8WWQ0 D246G   WD repeat domain 11 protein (Fragment).
Q8WWQ0 P1344L   WD repeat domain 11 protein (Fragment).

CCDS5209.1

Q13255 R684C   Metabotropic glutamate receptor 1 precursor (mGluR1).

CCDS5234.1

P03372 S341L   Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

CCDS5442.1

Q8N8U9 P640L   BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

CCDS5514.1

P00533 G598V Near domain interface Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

CCDS5600.1

Q14832 V271I   Metabotropic glutamate receptor 3 precursor (mGluR3).

CCDS5705.1

P01588 R103W   Erythropoietin precursor (Epoetin).

CCDS571.1

Q9NV38 I121V   CDNA FLJ10948 fis, clone PLACE1000142, weakly similar to 3- HYDROXYBUTYRYL-COA DEHYDRATASE (EC 4.2.1.55).

CCDS5754.1

Q8IYQ6 S137F    

CCDS5875.1

Q9H480 R355H   Epithelial calcium channel (Fragment).
Q9H480 R359H   Epithelial calcium channel (Fragment).

CCDS5881.1

P35523 R778G   Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CCDS5907.1

Q96F15 S55Y Near domain interface GTPase IMAP family member 5 (Immunity-associated nucleotide 4-like 1 protein) (Immunity-associated protein 3) (IAN-5).

CCDS6012.1

P06858 Q133K   Lipoprotein lipase precursor (EC 3.1.1.34) (LPL).

CCDS606.1

P07357 R484H   Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

CCDS6069.1

Q9NPG1 A315D   Frizzled-3 precursor (Fz-3) (hFz3).

CCDS6113.1

Q9Y3Q7-2 T583I   ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

CCDS6157.1

O75608 W145C   Acyl-protein thioesterase 1 (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I).

CCDS6239.1

P00918 K18T   Carbonic anhydrase 2 (EC 4.2.1.1) (Carbonic anhydrase II) (Carbonate dehydratase II) (CA-II) (Carbonic anhydrase C).

CCDS6280.1

Q7Z7G8 K3282T Near domain interface Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1).

CCDS6309.1

Q15006 V138M   Tetratricopeptide repeat protein KIAA0103.

CCDS6329.1

Q13822 H486Q   Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

CCDS645.1

Q96NW7 S1063T   Leucine-rich repeat-containing protein 7 (Protein LAP1) (Densin-180).

CCDS6612.1

Q9Y2H3 E240K   KIAA0967 protein.

CCDS686.1

P43088 H278L   Prostaglandin F2-alpha receptor (Prostanoid FP receptor) (PGF receptor) (PGF2 alpha receptor).

CCDS6930.1

O14656 S165Y   Torsin A precursor (Torsin family 1 member A) (Dystonia 1 protein).

CCDS7058.1

Q9NS39 R322H   Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (dsRNA adenosine deaminase B2) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2).

CCDS7149.1

Q05329 M415I   Glutamate decarboxylase 2 (EC 4.1.1.15) (Glutamate decarboxylase 65 kDa isoform) (GAD-65) (65 kDa glutamic acid decarboxylase).

CCDS7200.1

P07949 R330W   Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

CCDS7218.1

P10745 E406K Near domain interface Interphotoreceptor retinoid-binding protein precursor (IRBP) (Interstitial retinol-binding protein).

CCDS7258.1

Q12955 P1035S   Ankyrin-3 (ANK-3) (Ankyrin-G).

CCDS7436.1

P33261 P382L   Cytochrome P450 2C19 (EC 1.14.13.80) ((R)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 6-monooxygenase) (EC 1.14.13.49) ((S)- limonene 7-monooxygenase) (CYPIIC19) (P450-11A) (Mephenytoin 4- hydroxylase) (CYPIIC17) (P450-254C).

CCDS745.1

O75815 P404S   Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

CCDS7578.1

O15500 A56T    

CCDS7589.1

Q6ZWJ7 R466H   CDNA FLJ16213 fis, clone CTONG2024206.

CCDS7594.1

P16233 R354C Near domain interface Pancreatic triacylglycerol lipase precursor (EC 3.1.1.3) (Pancreatic lipase) (PL).

CCDS7976.1

Q9HB70 R192H    

CCDS8433.1

Q16099 G787E   Glutamate receptor, ionotropic kainate 4 precursor (Glutamate receptor KA-1) (KA1) (Excitatory amino acid receptor 1) (EAA1).

CCDS8487.1

Q9Y5Y6 T259S Near domain interface Suppressor of tumorigenicity protein 14 (EC 3.4.21.109) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

CCDS8599.1

O75613 E92K   ITIM-containing receptor MAFA-L (Mast cell function-associated antigen homolog).

CCDS8612.1

Q8IUW7 S97C Near domain interface  

CCDS8727.1

Q96M96 C565Y   FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

CCDS8734.1

Q9UBJ2 L580M   ATP-binding cassette sub-family D member 2 (Adrenoleukodystrophy- related protein) (hALDR) (Adrenoleukodystrophy-like 1).

CCDS8926.1

Q8NEX9 K284E Near domain interface Retinol dehydrogenase similar protein (Orphan short-chain dehydrogenase / reductase).

CCDS893.1

Q9H8W5 S451R   Tripartite motif-containing protein 45 (RING finger protein 99).

CCDS8973.1

Q6MZU8 E176K   Hypothetical protein DKFZp686C1178 (Fragment).

CCDS9465.1

O94991 S191N   SLIT and NTRK-like protein 5 precursor (Leucine-rich repeat-containing protein 11).

CCDS9540.1

Q14393-2 A601T   Growth-arrest-specific protein 6 precursor (GAS-6).

CCDS9591.1

Q92843 E131G   Apoptosis regulator Bcl-W (Bcl-2-like 2 protein).

CCDS9624.1

Q86U38 R542H   Uncharacterized protein C14orf21.

CCDS9632.1

P20718 V207M Near domain interface Granzyme H precursor (EC 3.4.21.-) (Cytotoxic T-lymphocyte proteinase) (Cathepsin G-like 2) (CTSGL2) (CCP-X) (Cytotoxic serine protease C) (CSP-C).

CCDS9678.1

Q96NI6 V63I   Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

CCDS9756.1

Q8NCM2 R673W Near domain interface Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (hEAG2).

CCDS992.1

Q8N1G0 C682S   Zinc finger protein 687.
Q8N1G0 Q681H   Zinc finger protein 687.

CCDS9926.1

Q8IW75 N52D   Serpin A12 precursor (Visceral adipose-specific serpin) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (OL-64).

CCDS9997.1

Q9UNW8-2 R156Q   Probable G-protein coupled receptor 132 (G2 accumulation protein).

ENST00000253728

  T270I Near domain interface  

ENST00000266524

  V765I    

ENST00000298216

  A199T Near ligand  

ENST00000323012

  Y371D Near domain interface  

ENST00000329763

  H184Q    

ENST00000331523

  Y184C    

ENST00000333066

  A599V    

ENST00000333744

  A77V Near domain interface  

ENST00000342479

  T100M    

ENST00000353590

  R288H    

ENST00000355324

  H87Q    

ENST00000359590

  A168T    

NP_000114

  Q621E    

NP_000305

  G132S    

NP_000510

  G57A    

NP_000519

  R950H    

NP_000528

  V76M    

NP_000710

  A49D    

NP_001003792

  I166V Near domain interface  

NP_001007796

  R54I    

NP_001010879

  T393A    

NP_001027024

  M445L    

NP_001027549

  F186I    

NP_001168

  T161I Near domain interface  

NP_001667

  Q712E    

NP_001727

  V190M    

NP_001997

  I207V    

NP_002224

  S61F    

NP_003852

  R35K    

NP_004236

  V198I    

NP_004360

  S521L    

NP_004659

  I1259V    

NP_005134

  G276R    

NP_005436

  A44V    

NP_006178

  R1073Q Near domain interface  

NP_006209

  G1049S    
  L866F    

NP_006725

  V133I    

NP_006840

  R303C    

NP_008853

  R1871Q    

NP_009075

  R64W    

NP_009298

  P487L    

NP_037365

  I208T Near domain interface  

NP_037416

  Q342H    

NP_055725

  R506T Near ligand  

NP_055791

  R1779W    

NP_055826

  P338T Near domain interface  

NP_055835

  S502I    

NP_055839

  R386Q    

NP_056009

  R588H    

NP_056014

  H146P    

NP_056041

  I637M    

NP_056046

  D993N    

NP_056051

  L562M    

NP_056162

  R238Q    

NP_056340

  C764S    

NP_056345

  I153M    

NP_057382

  R78H    

NP_057424

  D365V    

NP_057447

  R319Q    

NP_060868

  A774T    

NP_061198

  G205V    

NP_063947

  D252V    

NP_065070

  E1401V    

NP_065175

  G1021A    

NP_066305

  T206R    

NP_067546

  A84T    

NP_076433

  T89M    

NP_078921

  E26K    

NP_114065

  R634H    

NP_115541

  R1151C    

NP_443727

  K175R Near domain interface  

NP_620482

  R579K    

NP_689555

  A286E    

NP_689680

  E580K    

NP_775760

  I1372T    

NP_899234

  R862Q    

NP_955533

  N161D    
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References

1. Pieper U, Eswar N, Stuart AC et al. MODBASE, a database of annotated comparative protein structure models, Nucleic Acids Res 2002;30:255-259.
2. Sali A, Blundell TL. Comparative protein modelling by satisfaction of spatial restraints, J Mol Biol 1993;234:779-815.
3. Pettersen EF, Goddard TD, Huang CC et al. UCSF Chimera--a visualization system for exploratory research and analysis, J Comput.Chem. 2004;25:1605-1612.
4. Stuart AC, Ilyin VA, Sali A. LigBase: a database of families of aligned ligand binding sites in known protein sequences and structures, Bioinformatics 2002;18:200-201.
5. Davis FP, Sali A. PIBASE: a comprehensive database of structurally defined protein interfaces, Bioinformatics 2005;21:1901-1907.
6. Wu CH, Apweiler R, Bairoch A et al. (2006), 'The Universal Protein Resource (UniProt): an expanding universe of protein information', /Nucleic Acids Res/, pp. D187-191.
7. Kuhn RM, Karolchik D, Zweig AS et al. The UCSC genome browser database: update 2007, Nucleic Acids Res 2007;35:D668-673.